Immune Dysregulation

ALDH2 Sources

ALDH2 Deficiency References

  1. Edenberg, H. J. (2007). The Genetics of Alcohol Metabolism: Role of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Variants. Alcohol Research Health, 30(1), 5-13.
    PMID: 17718394 PMCID: PMC3860432
  2. Guang Yin, et al. (2007). Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Science, 98(8), 1248-1253.
    PMCID: PMC11159727 PMID: 17517051
  3. Brooks, P. J., & Theruvathu, J. A. (2005). DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol, 35(3), 187-193.
    PMID: 16054980
  4. Tadokoro, T., et al. (2025). Genetic Polymorphisms of ALDH2 and ADH1B in Alcohol-Induced Liver Injury: Molecular Mechanisms of Inflammation and Disease Progression in East Asian Populations. Int. J. Mol. Sci. 2025, 26(17), 8328.
    https://doi.org/10.3390/ijms26178328
  5. Seitz, H. K., & Stickel, F. (2010). Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism. Genes & Nutrition, 5(2), 121-128.
    PMCID: PMC2885165 PMID: 19847467
  6. Townsend, D. M., Tew, K. D., & Tapiero, H. (2003). The importance of glutathione in human disease. Biomedicine & Pharmacotherapy, 57(3-4), 145-155.
    PMID: 12818476 PMCID: PMC6522248
  7. Forman, H. J., et al. (2009). Glutathione: Overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine, 30(1-2), 1-12.
    doi: 10.1016/j.mam.2008.08.006 PMCID: PMC2696075 PMID: 18796312
  8. Lieber, C. S. (2000). Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases. Mt. Sinai Journal of Medicine, 67(1), 84-94.
    PMID: 10677787
  9. Shin, M., et al. (2017). Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea. Yonsei Medical Journal, 58(4), 689-696.
    PMID: 28540979 PMCID: PMC5447097
    DOI: 10.3349/ymj.2017.58.4.689

References for Non-alcohol Related ALDH2 Deficiency

  1. Edenberg, H. J. (2007). The Genetics of Alcohol Metabolism: Role of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Variants. Alcohol Research Health, 30(1), 5-13.
    PMID: 17718394 PMCID: PMC3860432
  2. Guang Yin, et al. (2007). Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Science, 98(8), 1248-1253.
    PMCID: PMC11159727 PMID: 17517051
  3. Brooks, P. J., & Theruvathu, J. A. (2005). DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol, 35(3), 187-193.
    PMID: 16054980
  4. Tadokoro, T., et al. (2025). Genetic Polymorphisms of ALDH2 and ADH1B in Alcohol-Induced Liver Injury: Molecular Mechanisms of Inflammation and Disease Progression in East Asian Populations. Int. J. Mol. Sci. 2025, 26(17), 8328.
    https://doi.org/10.3390/ijms26178328
  5. Seitz, H. K., & Stickel, F. (2010). Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism. Genes & Nutrition, 5(2), 121-128.
    PMCID: PMC2885165 PMID: 19847467
  6. Townsend, D. M., Tew, K. D., & Tapiero, H. (2003). The importance of glutathione in human disease. Biomedicine & Pharmacotherapy, 57(3-4), 145-155.
    PMID: 12818476 PMCID: PMC6522248
  7. Forman, H. J., et al. (2009). Glutathione: Overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine, 30(1-2), 1-12.
    doi: 10.1016/j.mam.2008.08.006
    PMCID: PMC2696075 PMID: 18796312
  8. Lieber, C. S. (2000). Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases. Mt. Sinai Journal of Medicine, 67(1), 84-94.
    PMID: 10677787
  9. Shin, M., et al. (2017). Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea. Yonsei Medical Journal, 58(4), 689-696.
    PMID: 28540979 PMCID: PMC5447097
    DOI: 10.3349/ymj.2017.58.4.689

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